Monthly Technical Information - 2019 ​

Risk-free interest rate

​Background Material.

The risk-free interest rate is the rate of return of a hypothetical investment with no risk of financial loss, over a given period of time. Since the risk-free rate can be obtained with no risk, any other investment having some risk will have to have a higher rate of return in order to induce any investors to hold it.  · With risk free rates, you’re adding the “inflation effect” TO the real rfr to get the nominal risk free rate. Because of the change in the use of the words real and nominal, it looks as if Real GDP is an inflation adjusted number, while NOMINAL risk free rate is an inflation adjusted number.

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A realistic estimation of the cost of capital is vital for companies when making investment - or transaction-related decisions. Risk-free rate, risk premium (consisting of market risk premium and beta), further risk premiums, such as country risk premium and terminal value growth rate basically.

Extrapolation method 30 years years. Smoothing period From to. Resulting risk free yield Selected risk free rate. Valuation date Reference date for the valuation. Also called appraisal or valuation date. There are basically two main conventions to specify a valuation date. They have both the same meaning: All relevant information available as of that date should be considered within the valuation. This includes available information for the estimation of an appropriate cost of capital.

We use variant i here. In consequence, the risk free rate as part of the cost of capital is specific for each valuation date. Currency Currencies for which Basiszinskurve. An appropriate discount rate should have the same currency nomination as the cash flow of your investment. Country risk premium The country risk premia reflect the latest bond ratings and appropriate default spreads for different countries. While these numbers can be used as rough estimates of country risk premiums, you may want to modify the premia to reflect your specific assessment.

To estimate the long term country risk premium, we start with the country rating and estimate the default spread for that rating based upon traded country bonds over a default free government bond rate.

This becomes a measure of the added country risk premium for that country. We usually add this default spread to the historical risk premium for a mature equity market estimated from historical data to estimate the total risk premium. For the risk free rate, we use the Svensson-Siegel method to determine interest rate estimates. These parameters are input factors for the Svensson function to determine the yield curve at a specific point of time. Compounding method Yield curves are provided in discrete and continuous terms.

However, you can choose how the interest rates should be presented. We convert the interest rates accordingly. Please refer to the technical appendix on our website for details. Investment horizon The investment horizon of your investment, i. If the investment horizon is indefinite - as usually assumed in business valuations - we recommend to apply a perpetual setting. Terminal growth rate The interest curve is based on the Svensson method. The corresponding rates are zero-coupon interest rates.

To value an investment with certain cash flows over a certain period the cash flows would need to be discounted with the respective zero rate. Or alternatively, based on the result of the this approach an coupon-yield can be determined resulting in an equivalent value. As this coupon rate would be dependent on the specific cash flow stream some simplified grwoth assumptions are often applied in practice.

Therefore we offer an option to calculate the coupon-yield curve for an perpetual investment with custom growth rates. Extrapolation method For the risk free rate we use the Svensson method to determine zero interest rate yield curves for up to 30 years. For a perpetual investment horizon we support two extrapolation methods for the determination of an corresponding coupon-yield rate in accordance with the two different IDW methods see Terminal growth rate: Smoothing period In general, the risk free rate curve fluctuates on a daily basis.

To avoid high fluctuations the IDW recommends to apply interest smoothing. It is typical to apply the interest smoothing over a period of 3 months or, alternatively, 90 days before the valuation date. This is the default setting in our calculation. However, we allow for individual selection of the smoothing period. Resulting risk free yield curve The chart shows the resulting risk free zero yield curve as of the selected valuation date based on the Svensson method.

The perpetual interest rate depicted by the horizontal line represents a coupon yield. The country risk premium is according to Damodaran.

Schätzung der Zerobond-Zinssätze nach der Svensson-Methode für 1 bis 30 Jahre Mit den Renditen börsennotierter deutscher Staatsanleihen existiert eine breite Datenbasis zur Ableitung von Basiszinssätzen aus Marktdaten. Zur Glättung von Marktschwankungen, Verwendung eines 3-Monatszeitraums vor dem Bewertungsstichtag Dieses Schatzverfahren ermöglicht die theoretisch stichtagsgenaue Ermittlung eines Zerobond-Zinssatzes für jede Laufzeit.

PRDM9 is a major determinant of meiotic recombination hot spots in humans and mice. A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. A positive but complex association between meiotic double-strand break hotspots and open chromatin in Saccharomyces cerevisiae. PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Structural similarities between topoisomerases that cleave one or both DNA strands.

An atypical topoisomerase II from archaea with implications for meiotic recombination. Prelude to a division. Annu Rev Cell Dev Biol Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation. Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination. Mapping of meiotic single-stranded DNA reveals double-strand-break hotspots near centromeres and telomeres.

Separation of DNA replication from the assembly of break-competent meiotic chromosomes. SWI1 is required for meiotic chromosome remodeling events. Functional interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex. J Cell Sci The multiple roles of the Mre11 complex for meiotic recombination. Use of a recombination reporter insert to define meiotic recombination domains on chromosome III of Saccharomyces cerevisiae.

Mol Cell Biol Direct coupling between meiotic DNA replication and recombination initiation. Association of Mre11p with double-strand break sites during yeast meiosis. Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. Genetic recombination is directed away from functional genomic elements in mice.

Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans. Distinct histone modifications define initiation and repair of meiotic recombination in the mouse.

Homologous chromosome associations and nuclear order in meiotic and mitotically dividing cells of budding yeast. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. A link between meiotic prophase progression and crossover control.

Meiotic DNA breaks associated with recombination in S. The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.

Synaptonemal complex assembly in C. Evolutionary conservation of meiotic DSB proteins: More than just Spo High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. A component of C.

Meiotic recombination in Schizosaccharomyces pombe: A paradigm for genetic and molecular analysis. In Recombination and meiosis ed. Egel R, Lankenau DH , pp. Meiotic recombination and its regulation. Trends Cell Biol A natural meiotic DNA break site in Schizosaccharomyces pombe is a hotspot of gene conversion, highly associated with crossing over. Nat Cell Biol Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination.

Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast. The multiple faces of Set1. Biochem Cell Biol Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation.

J Biol Chem AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana. A high throughput genetic screen identifies new early meiotic recombination functions in Arabidopsis thaliana. Meiotic recombination in C. Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. J Exp Bot Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.

Mug20, a novel protein associated with linear elements in fission yeast meiosis. A WD repeat protein, Rec14, essential for meiotic recombination in Schizosaccharomyces pombe.

Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae. Protein determinants of meiotic DNA break hot spots. Evolutionarily diverse determinants of meiotic DNA break and recombination landscapes across the genome. A second generation human haplotype map of over 3. Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination.

Nucleic Acids Res Molecular and genetic analysis of REC , an early meiotic recombination gene in yeast. Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae. Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis.

Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast. The yeast Ski complex: Crystal structure and RNA channeling to the exosome complex.

Genetics of meiotic prophase I in plants. Annu Rev Plant Biol Genetics of mammalian meiosis: Regulation, dynamics and impact on fertility.

Nat Rev Genet A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. C elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression. The synaptonemal complex shapes the crossover landscape through cooperative assembly, crossover promotion and crossover inhibition during Caenorhabditis elegans meiosis. Cyclin-dependent kinase directly regulates initiation of meiotic recombination.

An asymmetric chromosome pair undergoes synaptic adjustment and crossover redistribution during Caenorhabditis elegans meiosis: Implications for sex chromosome evolution. The landscape of recombination in African Americans. Multiple modes of chromatin configuration at natural meiotic recombination hot spots in fission yeast. The FK binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. In Molecular genetics of recombination ed.

Aguilera A, Rothstein R , pp. Crossover invariance determined by partner choice for meiotic DNA break repair. Relationship of DNA double-strand breaks to synapsis in Drosophila. J Cell Biol Meiotic recombination protein Rec Where the crossovers are: Recombination distributions in mammals. Nat Rev Genet 5: Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Numerical constraints and feedback control of double-strand breaks in mouse meiosis.

Spatial organization and dynamics of the association of Rec and Rec with meiotic chromosomes. Mechanisms and control of meiotic recombination initiation. Curr Top Dev Biol Spo11 and the formation of DNA double-strand breaks in meiosis. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family.

Sister cohesion and structural axis components mediate homolog bias of meiotic recombination. How could it work? A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Fine-scale recombination rate differences between sexes, populations and individuals.

Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Mol Biol Cell Initiation of meiotic recombination in mammals. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. The Drosophila zinc finger protein trade embargo is required for double strand break formation in meiosis.

ATM controls meiotic double-strand-break formation. Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombe. Saccharomyces cerevisiae Mer2, Mei4 and Rec form a complex required for meiotic double-strand break formation.

The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression. Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice. The impressionistic landscape of meiotic recombination. The location and structure of double-strand DNA breaks induced during yeast meiosis: Evidence for a covalently linked DNA-protein intermediate.

The modest cousins of synaptonemal complexes. S pombe meiotic linear elements contain proteins related to synaptonemal complex components. Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe. Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.

Recombinational DNA double-strand breaks in mice precede synapsis. Interactions between Mei4, Rec, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae.

Examination of the intron in the meiosis-specific recombination gene REC in Saccharomyces. Mol Gen Genet Analysis of meiotic recombination pathways in yeast Saccharomyces cerevisiae. A large-scale screen in S.

Making chromosomes hot for breakage. HTPdependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. A key regulator in the initiation of DNA replication.

J Cell Physiol Meiotic synapsis in the absence of recombination. Synthesis-dependent strand annealing in meiosis. The fine-scale structure of recombination rate variation in the human genome. Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila females. Crossover distribution and frequency are regulated by him-5 in Caenorhabditis elegans.

A novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis. The meiotic protein SWI1 is required for axial element formation and recombination initiation in Arabidopsis. A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. Spatiotemporal regulation of meiotic recombination by Liaisonin.

Chromosome cores and chromatin at meiotic prophase. The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis. Characterization of rec7 , an early meiotic recombination gene in Schizosaccharomyces pombe. Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing.

Mouse mutants from chemically mutagenized embryonic stem cells. Regulating the formation of DNA double-strand breaks in meiosis. Correlation between premeiotic DNA replication and chromatin transition at yeast recombination initiation sites.

J Mol Biol A fine-scale map of recombination rates and hotspots across the human genome. A common sequence motif associated with recombination hot spots and genome instability in humans. Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Chromosome-wide regulation of meiotic crossover formation in Caenorhabditis elegans requires properly assembled chromosome axes.

Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.

Rad3-Cds1 mediates coupling of initiation of meiotic recombination with DNA replication. Mei4 -dependent transcription as a potential target of meiotic checkpoint. Changes in chromatin structure at recombination initiation sites during yeast meiosis. Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.

Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. A germline clone screen for meiotic mutants in Drosophila melanogaster. A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Spoaccessory proteins link double-strand break sites to the chromosome axis in early meiotic recombination. Prdm9 controls activation of mammalian recombination hotspots. Coordination of meiotic recombination, pairing, and synapsis by PHS1.

Targeted stimulation of meiotic recombination. Meiotic recombination hot spots and cold spots. Nat Rev Genet 2: Genome-wide map of nucleosome acetylation and methylation in yeast. Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spodependent genome fragmentation during meiosis. Mei1 is epistatic to Dmc1 during mouse meiosis. Comparative genomics of hemiascomycete yeasts: Genes involved in DNA replication, repair, and recombination.

Mol Biol Evol Sensing of DNA non-homology lowers the initiation of meiotic recombination in yeast. Centromere-proximal crossovers are associated with precocious separation of sister chromatids during meiosis in Saccharomyces cerevisiae.

The mouse Spo11 gene is required for meiotic chromosome synapsis. Methylation of lysine 4 on histone H3: Intricacy of writing and reading a single epigenetic mark. Mechanism of eukaryotic homologous recombination. Annu Rev Biochem Genome destabilization by homologous recombination in the germ line.

Meiotic association between Spo11 regulated by Rec, Rec and Rec Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. Meiotic effects of DNA-defective cell division cycle mutations of Saccharomyces cerevisiae. Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis.

Cdc7p-Dbf4p becomes famous in the cell cycle. Identification of novel Drosophila meiotic genes recovered in a P-element screen. The spatial regulation of meiotic recombination hotspots: Are all DSB hotspots crossover hotspots? Exp Cell Res Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine Molecular implementation and physiological roles for histone H3 lysine 4 H3K4 methylation.

Curr Opin Cell Biol Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. Pachytene arrest and other meiotic effects of the start mutations in Saccharomyces cerevisiae. Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. The yeast Red1 protein localizes to the cores of meiotic chromosomes. B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis.

Set1 in required for meiotic S-phase onset, double-strand break formation and middle gene expression. Spp1, a member of the Set1 complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes.

SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe. Identification of DSB-1, a protein required for initiation of meiotic recombination in C.

Functional interactions among members of the meiotic initiation complex in fission yeast. Double-strand breaks at an initiation site for meiotic gene conversion. From meiosis to postmeiotic events: Homologous recombination is obligatory but flexible.

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Thus, it is possible that the effect of HIM on DSB formation is indirect through histone modifications that alter chromosome structure and make it amenable for SPO catalytic activity. Although this point might seem obvious to some, transaction costs MUST be included in the calculation of Sharpe ratio in order for it to be realistic.

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It is typical to apply the interest smoothing over a period of 3 months or, alternatively, 90 days before the valuation date.

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